- Two FRM (Fondation pour la Recherche Médicale) grants on Addiction awarded to OptoPath scientists
OptoPath scientists have been awarded two very competitive FRM grants: Serge Ahmed for a research project based on “Decision-making in pathological addiction to cocaine: causal role of orbitofrontal neuronal activity” and Veronique Deroche-Gamonet for a project entitled “Is addiction to nicotine a single entity? A preclinical model to identify subpopulations which are differentially sensitive to treatment”[ read more ]
- Prefrontal neuronal assemblies temporally control fear behaviour
A publication in Nature by Cyril Dejean from Cyril Herry team[ read more ]
- When experts in obesity meet experts in memory
Cutting-edge translational research in obesity-linked memory deficits[ read more ]
- "The brain strikes back: Hypothalamic targets for peripheral CB1 receptor inverse agonism"
A publication in Molecular Metabolism by Daniela Cota.[ read more ]
- A publication in Nature Neuroscience by Cyril Herry's team
Internally generated 4 hz oscillations synchronize prefrontal-amygdala neuronal circuits during fear behaviour. Fear response to traumatic or threatening situations helps us evade or escape danger. At the same time fear response is learned in the form of association between stimulus or situation and the presence of a stressor (e.g. physical danger). This association is very powerful and leaves a memory trace that persists for years after a single experience, generating profound structural and functional changes in the brain that can potentially develop into post-traumatic stress and other anxiety-related disorders.[ read more ]
- CB1 cannabinoid receptor determines metabolic responses to diet and leptin
In this recent publication, Daniela Cota's group shows that CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin, therefore demonstrating that CB1 receptors in VMN neurons provide a molecular switch adapting the organism to dietary change.[ read more ]
- OptoPath represented at the 12th "Colloque de la Société des Neurosciences" in Montpellier, France
OptoPath was represented by our industrial partner Imetronic at the 12th "Colloque de la Société des Neurosciences " , which took place in Montpellier (France) in May 2015[ read more ]
- Training in endomicroscopy in vivo-Use of the Cellvizio system
Study of cerebral vascular network by endomicroscopy in vivo. Theoretical and practical training in the use of Cellvizio system has been organized on June 13th and 14th, 2017[ read more ]
- A second publication for Optopath in Neuropsychopharmacology
Cocaine seeking: The dual role of the prelimbic cortex in High frequency users. Coupling cocaine intravenous self-administration with optogenetic, Dr Deroche-Gamonet in collaboration with Dr Herry reveals that high frequency cocaine intake promotes a PL-dependent control of cocaine seeking, with the PL exerting a facilitatory effect on cocaine-induced resinstatement and an inhibitory effect on cocaine self-administration. Individual differences in cocaine-induced PL activation might be a source of vulnerability for poorly controlled cocaine-induced seeking and/or cocaine intake.[ read more ]
- An innovative system : Morphing Context for Fear Conditioning without animal handling
Contextual fear-related studies require moving the rodent from one context to another, introducing non-specific neuronal activation. The Morphing Context apparatus, that we developed with...[ read more ]
- The CAJAL School in OPTOPATH
OptoPath hosted some courses of the Cajal School "Connectomics: from Micro- to Meso- and Macro-Scales" (2-21 October 2017, Bordeaux Neurocampus, France)[ read more ]
- Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence
A new publication in Neuropsychopharmacology by Vernon Garcia-Rivas from Véronique Deroche-Gamonet group[ read more ]
- COCADDICT: an ERA-NET Neuron-funded project
A French-Canadian-German consortium for a translational study of cocaine addiction-related brain network reorganization: Experimental psychology combined with neuroimaging and electrophysiology in humans and rodents.[ read more ]
- "Prefrontal-Periaqueductal Gray-Projecting Neurons Mediate Context Fear Discrimination"
A publication in Neuron by Cyril Herry's team.[ read more ]
- "Temporal binding function of dorsal CA1 is critical for declarative memory formation"
A New Publication In PNAS By Aline Marighetto Team[ read more ]
- "Abnormal wiring of CCK+ basket cells disrupts spatial information coding"
A publication in Nature Neuroscience with Aline Marighetto.[ read more ]
- Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies
In this publication in Biological Psychiatry, Cyril Dejean and Cyril Herry review the functional role of distinct neuronal structures involved in the expression and recovery of conditioned fear responses and detail the non-canonical neuronal circuits recently identified to play a key role in fear expression. The identification of neuronal circuits dedicated to fear expression may promote the development of new therapeutical strategies for anxiety disorders and related psychiatric conditions.[ read more ]
- OptoPath as if you were there
A virtual visit of OptoPath is now available online. It allows you to visit our premises and appreciate our cutting-edge equipment.[ read more ]
- First publication for OptoPath in Nature
Controlling fear: Prefrontal cortex interneurons in action. Using multi-site electrophysiology and optogenetic, Dr Herry’s group reveals that persistent fear behavior, which is at the core of psychiatric conditions such as anxiety disorders, might be finely regulated at the level of specific prefrontal inhibitory circuits.[ read more ]
- OptoPath represented at the 9th FENS Forum of Neuroscience
OptoPath was represented by our industrial partner Imetronic at the 9th FENS Forum of Neuroscience, which took place in Milan (Italy) in July 2014.[ read more ]
- CocAddict Consortium meeting in Bordeaux
Members of the European ERA-NET NEURON (Network of EUROpean funding for Neuroscience research). COCADDICT met in Bordeaux on July, 7th and 8th 2015, in the premises of Magendie Neurocenter. Specialized in cocaine addiction mechanisms, this network members develop preclinical and clinical research projects on neural mechanisms involved in cocaine addiction process. Coming from Canada and Germany, the neuroimaging and electrophysiology experts of this consortium came in Bordeaux to share their results with their French partners and promote the development of scientific collaborations.[ read more ]
- "Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling"
A new publication in Gut with Daniela Cota.[ read more ]
- The University of Bordeaux supports COCADDICT
Through the Bordeaux International Support program, COCADDICT will be able to support exchanges between its Canadian and French partners[ read more ]
- Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice
A publication from Daniela Cota team in Endocrinology (2014, Dec 2)[ read more ]
- Use of Cellvizio technology to visualize cerebral vessels network in a new publication from Jean-Luc Morel
TRPP2 modulates ryanodine- and inositol-1,4,5-trisphosphate receptors-dependent Ca2+ signals in opposite ways in cerebral arteries[ read more ]
- "Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages"
A publication in JCI with Daniela Cota.[ read more ]
- Deux chercheurs d'OptoPath dans le magazine "La Recherche"
Pour son numéro spécial d’Aout 2014 « la bibliothèque idéale – les 40 livres de science indispensables », le magazine « La Recherche » a demandé à des chercheurs de toutes disciplines et de tous horizons intellectuels quel était leur livre de science préféré, celui qui les avait inspirés, fait rêver, bousculés parfois.[ read more ]
- Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide
A publication from Jean-Luc Morel in European Journal of Pharmacology[ read more ]
- Organisation of a workshop on in depth tissue imaging on small-animal within the "Imaging the Cell" 8th meeting
In the frame of the 8th Imaging the Cell international meeting, a workshop on small-animal and in depth tissue imaging was organized on OptoPath premises. Cellvizio equipement was used to...[ read more ]
- "MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future."
A Review in European Journal of Endocrinology with Daniela Cota.[ read more ]