Abrous's team in Molecular Psychiatry - The temporal origin of dentate granule neurons dictates their role in spatial memory

Abrous’s team, in collaboration with Cyril Herry, Véronique Deroche, and Daniela Cota, has recently revealed the first evidence of an adolescence and adulthood neurogenesis in the hippocampal spatial memory.

The combination of functional imaging, retroviral and optogenetic approaches to tag and silence dentate granule neurons (DGNs) has pointed out that only the neurons born during adolescence, and not those born in embryos or neonates, are involved in spatial memory processing, a role that is later assumed by neurons generated during adulthood.

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