Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, A. Marighetto's team shows in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by...

Contextual fear-related studies require moving the rodent from one context to another, introducing non-specific neuronal activation. The Morphing Context apparatus, that we developed with Imetronic, solves this issue. It is not the rodent that is moved, rather it's the context that's remotely changed. The Morphing context allows to record neurophysiologic activity while leaving the rodent...