A rodent platform entirely dedicated to innovation in experimental psychopathology 

Headline News
Save the date : Training in endomicroscopy in vivo-Use of the Cellvizio system

Study of cerebral vascular network by endomicroscopy in vivo. Theoretical and practical training in the use of Cellvizio system June 13-14, 2017 Register Now!

[ read more ]
A new Lab Manager for OptoPathA new Lab Manager for OptoPath


[ read more ]
Prefrontal neuronal assemblies temporally control fear behaviourPrefrontal neuronal assemblies temporally control fear behaviour

A publication in Nature by Cyril Dejean from Cyril Herry team

[ read more ]
Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine DependenceIndividual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence

A new publication in Neuropsychopharmacology by Vernon Garcia-Rivas from Véronique Deroche-Gamonet group

[ read more ]
A publication in Nature Neuroscience by Cyril Herry's team

Internally generated 4 hz oscillations synchronize prefrontal-amygdala neuronal circuits during fear behaviour. Fear response to traumatic or threatening situations helps us evade or escape danger. At the same time fear response is learned in the form of association between stimulus or situation and the presence of a stressor (e.g. physical danger). This association is very powerful and leaves a memory trace that persists for years after a single experience, generating profound structural and...

[ read more ]
An innovative system : Morphing Context for Fear Conditioning without handling the animal

Contextual fear-related studies require moving the rodent from one context to another, introducing non-specific neuronal activation. The Morphing Context apparatus, that we developed with Imetronic, solves this issue. It is not the rodent that is moved, rather it's the context that's remotely changed. The Morphing context allows to record neurophysiologic activity while leaving the rodent undisturbed as it discriminates between fearful and non-fearful contexts. See video for more details.

[ read more ]

OptoPath combines the expertise of neurobiologists, electrophysiologists and experimental psychologists for the identification of new therapeutic targets against 4 major psychological disorders: Addiction, Obesity, PTSD/Anxiety-related disorders and Memory deficits.

Their efforts have been directed towards the development of:

  • Innovative rodent behavioral models of these highly incident psychopathologies with complex behavioral disturbances. To be as close as possible from the human symptomatology, the diagnosis criteria and clinical characteristics of the pathologies of interest have been operationalized into rodents.
  • Cutting edge tools for neurobiological investigations coupling technologies such as multi-sites electrophysiology, optogenetics and deep brain vascular imaging in behaving rodents.

Combining these innovative animal models and cutting-edge technologies, OptoPath provides :

  • A large range of in vivo assays to evaluate the safety/therapeutic effects of novel drugs in the context of 4 major psychopathologies: