A rodent platform entirely dedicated to innovation in experimental psychopathology 

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OptoPath as if you were there OptoPath as if you were there

A virtual visit of OptoPath is now available online. It allows you to visit our premises and appreciate our cutting-edge equipment.

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Training in endomicroscopy in vivo-Use of the Cellvizio system

Study of cerebral vascular network by endomicroscopy in vivo. Theoretical and practical training in the use of Cellvizio system has been organized on June 13th and 14th, 2017

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A new Lab Manager for OptoPathA new Lab Manager for OptoPath

 

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Prefrontal neuronal assemblies temporally control fear behaviourPrefrontal neuronal assemblies temporally control fear behaviour

A publication in Nature by Cyril Dejean from Cyril Herry team

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Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine DependenceIndividual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence

A new publication in Neuropsychopharmacology by Vernon Garcia-Rivas from Véronique Deroche-Gamonet group

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A publication in Nature Neuroscience by Cyril Herry's team

Internally generated 4 hz oscillations synchronize prefrontal-amygdala neuronal circuits during fear behaviour. Fear response to traumatic or threatening situations helps us evade or escape danger. At the same time fear response is learned in the form of association between stimulus or situation and the presence of a stressor (e.g. physical danger). This association is very powerful and leaves a memory trace that persists for years after a single experience, generating profound structural and functional changes in the brain that can potentially develop into post-traumatic stress and other anxiety-related disorders.

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An innovative system : Morphing Context for Fear Conditioning without handling the animal

Contextual fear-related studies require moving the rodent from one context to another, introducing non-specific neuronal activation. The Morphing Context apparatus, that we developed with...

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When experts in obesity meet experts in memoryWhen experts in obesity meet experts in memory

Cutting-edge translational research in obesity-linked memory deficits

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Organisation of a workshop on in depth tissue imaging on small-animal within the "Imaging the Cell" 8th meetingOrganisation of a workshop on in depth tissue imaging on small-animal within the "Imaging the Cell" 8th meeting

In the frame of the 8th Imaging the Cell international meeting, a workshop on small-animal and in depth tissue imaging was organized on OptoPath premises. Cellvizio equipement was used to...

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Use of Cellvizio technology to visualize cerebral vessels network in a new publication from Jean-Luc MorelUse of Cellvizio technology to visualize cerebral vessels network in a new publication from Jean-Luc Morel

TRPP2 modulates ryanodine- and inositol-1,4,5-trisphosphate receptors-dependent Ca2+ signals in opposite ways in cerebral arteries

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Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic StrategiesNeuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies

In this publication in Biological Psychiatry, Cyril Dejean and Cyril Herry review the functional role of distinct neuronal structures involved in the expression and recovery of conditioned fear responses and detail the non-canonical neuronal circuits recently identified to play a key role in fear expression. The identification of neuronal circuits dedicated to fear expression may promote the development of new therapeutical strategies for anxiety disorders and related psychiatric conditions.

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CocAddict Consortium meeting in BordeauxCocAddict Consortium meeting in Bordeaux

Members of the European ERA-NET NEURON (Network of EUROpean funding for Neuroscience research). COCADDICT met in Bordeaux on July, 7th and 8th 2015, in the premises of Magendie Neurocenter. Specialized in cocaine addiction mechanisms, this network members develop preclinical and clinical research projects on neural mechanisms involved in cocaine addiction process. Coming from Canada and Germany, the neuroimaging and electrophysiology experts of this consortium came in Bordeaux to share their results with their French partners and promote the development of scientific collaborations.

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OptoPath represented at the 12th "Colloque de la Société des Neurosciences"  in Montpellier, FranceOptoPath represented at the 12th "Colloque de la Société des Neurosciences" in Montpellier, France

OptoPath  was represented by our industrial partner Imetronic  at the 12th "Colloque de la Société des Neurosciences " ,  which took place in Montpellier (France) in May 2015

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OptoPath new building ready to move in!!!OptoPath new building ready to move in!!!

 

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Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide

A publication from Jean-Luc Morel in European Journal of Pharmacology

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Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male miceCannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice

A publication from Daniela Cota team in Endocrinology (2014, Dec 2)

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OptoPath represented  at the 9th FENS Forum of NeuroscienceOptoPath represented at the 9th FENS Forum of Neuroscience

OptoPath  was represented by our industrial partner Imetronic  at the 9th FENS Forum of Neuroscience,  which took place in Milan (Italy) in July 2014.

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Two FRM (Fondation pour la Recherche Médicale) grants on Addiction awarded to OptoPath scientistsTwo FRM (Fondation pour la Recherche Médicale) grants on Addiction awarded to OptoPath scientists

OptoPath scientists have been awarded two very competitive FRM grants: Serge Ahmed for a research project based on “Decision-making in pathological addiction to cocaine: causal role of orbitofrontal neuronal activity” and Veronique Deroche-Gamonet for a project entitled “Is addiction to nicotine a single entity? A preclinical model to identify subpopulations which are differentially sensitive to treatment”

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CB1 cannabinoid receptor determines metabolic responses to diet and leptinCB1 cannabinoid receptor determines metabolic responses to diet and leptin

In this recent publication, Daniela Cota's group shows that CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin, therefore demonstrating that CB1 receptors in VMN neurons provide a molecular switch adapting the organism to dietary change.

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COCADDICT: an ERA-NET Neuron-funded projectCOCADDICT: an ERA-NET Neuron-funded project

A French-Canadian-German consortium for a translational study of cocaine addiction-related brain network reorganization: Experimental psychology combined with neuroimaging and electrophysiology in humans and rodents.

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Deux chercheurs d'OptoPath dans le magazine "La Recherche"Deux chercheurs d'OptoPath dans le magazine "La Recherche"

Pour son numéro spécial d’Aout 2014 « la bibliothèque idéale – les 40 livres de science indispensables », le magazine « La Recherche » a demandé à des chercheurs de toutes disciplines et de tous horizons intellectuels quel était leur livre de science préféré, celui qui les avait inspirés, fait rêver, bousculés parfois.

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The University of Bordeaux supports COCADDICTThe University of Bordeaux supports COCADDICT

Through the Bordeaux International Support  program, COCADDICT will be able to support exchanges between its Canadian and French partners

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A second publication for Optopath in Neuropsychopharmacology

Cocaine seeking: The dual role of the prelimbic cortex in High frequency users. Coupling cocaine intravenous self-administration with optogenetic, Dr Deroche-Gamonet in collaboration with Dr Herry reveals that high frequency cocaine intake promotes a PL-dependent control of cocaine seeking, with the PL exerting a facilitatory effect on cocaine-induced resinstatement and an inhibitory effect on cocaine self-administration. Individual differences in cocaine-induced PL activation might be a source of vulnerability for poorly controlled cocaine-induced seeking and/or cocaine intake.

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First publication for OptoPath in NatureFirst publication for OptoPath in Nature

Controlling fear: Prefrontal cortex interneurons in action. Using multi-site electrophysiology and optogenetic, Dr Herry’s group reveals that persistent fear behavior, which is at the core of psychiatric conditions such as anxiety disorders, might be finely regulated at the level of specific prefrontal inhibitory circuits.

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