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A rodent platform entirely dedicated to innovation in experimental psychopathology 

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Save the date : Training in optogeneticsSave the date : Training in optogenetics

Training in Optogenetics coupled with in vivo electrophysiology - Hands on course - November 23-25, 2016

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A publication in Nature Neuroscience by Cyril Herry's team

Internally generated 4 hz oscillations synchronize prefrontal-amygdala neuronal circuits during fear behaviour. Fear response to traumatic or threatening situations helps us evade or escape danger. At the same time fear response is learned in the form of association between stimulus or situation and the presence of a stressor (e.g. physical danger). This association is very powerful and leaves a memory trace that persists for years after a single experience, generating profound structural and...

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An innovative system : Morphing Context for Fear Conditioning without handling the animal

Contextual fear-related studies require moving the rodent from one context to another, introducing non-specific neuronal activation. The Morphing Context apparatus, that we developed with Imetronic, solves this issue. It is not the rodent that is moved, rather it's the context that's remotely changed. The Morphing context allows to record neurophysiologic activity while leaving the rodent undisturbed as it discriminates between fearful and non-fearful contexts. See video for more details.

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When experts in obesity meet experts in memory When experts in obesity meet experts in memory

Cutting-edge translational research in obesity-linked memory deficits

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Organisation of a workshop on in depth tissue imaging on small-animal within the "Imaging the Cell" 8th meetingOrganisation of a workshop on in depth tissue imaging on small-animal within the "Imaging the Cell" 8th meeting

In the frame of the 8th Imaging the Cell international meeting, a workshop on small-animal and in depth tissue imaging was organized on OptoPath premises. Cellvizio equipement was used to investigate cerebral and vascular functions in vivo in rodents.

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Use of Cellvizio technology to visualize cerebral vessels network in a new publication from Jean-Luc MorelUse of Cellvizio technology to visualize cerebral vessels network in a new publication from Jean-Luc Morel

TRPP2 modulates ryanodine- and inositol-1,4,5-trisphosphate receptors-dependent Ca2+ signals in opposite ways in cerebral arteries

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OptoPath combines the expertise of neurobiologists, electrophysiologists and experimental psychologists for the identification of new therapeutic targets against 4 major psychological disorders: Addiction, Obesity, PTSD/Anxiety-related disorders and Memory deficits.

Their efforts have been directed towards the development of:

  • Innovative rodent behavioral models of these highly incident psychopathologies with complex behavioral disturbances. To be as close as possible from the human symptomatology, the diagnosis criteria and clinical characteristics of the pathologies of interest have been operationalized into rodents.
  • Cutting edge tools for neurobiological investigations coupling technologies such as multi-sites electrophysiology, optogenetics and deep brain vascular imaging in behaving rodents.

Combining these innovative animal models and cutting-edge technologies, OptoPath provides :

  • A large range of in vivo assays to evaluate the safety/therapeutic effects of novel drugs in the context of 4 major psychopathologies:

ADDICTION

OBESITY

PTSD-ANXIETY MEMORY DEFICITS


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